Senior Research Associate, In vivo Pharmacology

4 нед. назад

СШАSeniorOnsite

in vivo studiesrodent modelsmolecular biologycell biologyhistology

Senior Research Associate responsible for in vivo rodent studies and coordination of pharmacology projects in biotechnology.

О компании

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We recognize that great candidates often bring unique strengths without fulfilling every qualification . If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.
Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
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Обязанности

Conduct in vivo (mouse) studies to characterize and assess the function, pharmacokinetics, and biodistribution of Synteins TM , with increasing ownership of study design and interpretation.
Perform hands-on dosing of mice (including intravenous and other routes) and isolation/processing of mouse blood and tissues.
Comply with IACUC regulations regarding animal welfare and care.
Collect and prepare tissues for histology, including fixation and embedding.
Execute and optimize lab procedures such as tissue lysis and cell isolation, ELISA, Western blot, RNA/DNA extraction, qPCR, and related cell/molecular biology assays supporting in vivo studies, including some cell culture.
Coordinate with CROs to support the execution of external in vivo studies, including formulation and shipment of compounds.
Analyze, interpret, and accurately document study and assay results in an electronic lab notebook and present findings in internal meetings.
Apply troubleshooting and data analysis skills to resolve issues and improve study quality and throughput.
Collaborate with the Pharmacology team and cross-functionally to support lead optimization and platform advancement.

Требования

Required Qualifications
BS in Biology or related discipline with 5–7 years of relevant research experience, or MS with 3–5 years of relevant experience, ideally in a biotech or pharmaceutical setting.
Well-established, independent experience with rodent in vivo dosing and handling techniques with expertise in multiple routes of substance administration (e.g., PO, IP, IV, SC) and ability to efficiently execute study protocols involving multiple blood collection time points.
Experience in tissue dissection and preparation for RNA, protein analysis, and histology, including fixation and embedding.
Demonstrated ability to execute or learn various molecular and cell biology techniques, such as ELISA, Western blot, qPCR, cell-based functional assays, and flow cytometry.
Proficiency with software such as Excel, GraphPad Prism, and PowerPoint for experimental documentation and data analysis/presentation.
Strong organizational and analytical problem-solving skills, with meticulous attention to detail and industry-level experience with best practices related to data documentation and integrity.
Demonstrated ability to work independently and collaboratively across highly skilled, cross-functional teams in a fast-paced, entrepreneurial, and technically complex environment.
Preferred Qualifications
Extensive experience in cell culture techniques, including primary cell isolation, culture, characterization.
Experience with tissue sectioning and immunohistochemistry techniques, including antibody validation, multiplexing, and imaging.
Experience in flow cytometry and data analysis (e.g., FlowJo) is a plus.

Условия

The salary range for this role is $81,000 - $107,250. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. , Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on , Inc's good faith estimate as of the date of publication and may be modified in the future.

Другое

Company Description: , Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins TM , a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology.
was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.
The Role: We are looking for a highly motivated, broadly skilled Senior Research Associate to join our growing Pharmacology team. In this role, the successful candidate will be responsible for hands-on execution of rodent in vivo studies as well as coordination of studies with contract labs to support the progression of ’ pipeline. The incumbent may also contribute to in vitro and ex-vivo pharmacology activities to progress projects and the platform, including molecular and cell biology assays and histology. This role will collaborate cross-functionally with a diverse design-make-test team across and have the opportunity to impact platform and company growth.