СШАPrincipal Scientist, Pharmacology
1 мес. назад
СШАLeadOnsite
pharmacokineticspharmacodynamicsmolecular biologyassay development
Lead molecular biology strategy and execution for RNA therapeutic candidate studies in pharmacology.
О компании
- Nosis Bio is a well-funded biotech startup focused on cell-specific delivery of RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts who believe targeted extrahepatic delivery is the key to making RNA therapies the standard of care for a wide range of chronic diseases. We combine deep expertise in receptor biology, generative AI, and high-throughput in vivo data generation to accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech companies.
Обязанности
- We are seeking a Principal Scientist in Pharmacology to lead molecular biology strategy and execution for studies that characterize the pharmacokinetics, pharmacodynamics, biodistribution, target engagement, and activity of RNA therapeutic candidates. This hands-on scientific leadership role will own studies from experimental design through data interpretation and integrate molecular readouts with in vivo and program data to guide development decisions.
- The ideal candidate will bring deep expertise in quantitative molecular biology, assay development, and analysis of complex biological samples, with a record of setting technical direction, solving ambiguous scientific problems, and working effectively across pharmacology, discovery biology, chemistry, and data science. Title will be commensurate with experience.
- ● Design and lead quantitative molecular biology studies supporting pharmacokinetic, pharmacodynamic, biodistribution, target engagement, and gene expression assessments
- ● Develop, optimize, qualify, and oversee workflows for RNA and DNA extraction, cDNA synthesis, RT-qPCR, qPCR, ddPCR, and related molecular assays across programs
- ● Establish robust sample-processing workflows across cells, tissues, and biofluids, including homogenization, lysis, cleanup, quantification, normalization, and RNase-free handling
- ● Translate program questions into study strategies with appropriate controls, acceptance criteria, replication, timelines, and sample requirements
- ● Analyze and integrate complex datasets, including relative and absolute quantification, assay performance metrics, and relationships among molecular, exposure, efficacy, and other pharmacology readouts
- ● Lead troubleshooting and root-cause investigations for assay and instrument performance, and implement durable improvements to experimental workflows
- ● Establish and maintain SOPs, assay qualification summaries, data analysis templates, and training materials that support reproducible execution across the team
- ● Ensure accurate, real-time documentation in the electronic lab notebook, including protocols, raw data, deviations, quality-control decisions, and scientific interpretation
- ● Coordinate cross-functionally so sample generation, handling, analysis, and reporting remain aligned with study objectives and program timelines
- ● Present data with clear context, controls, conclusions, and recommendations, and use the results to guide experimental plans and program decisions
- ● Lead quantitative molecular biology strategy across one or more pharmacology programs, aligning assay plans with biological questions, technical feasibility, and program priorities
- ● Own molecular assay platforms end to end, including capability building, performance tracking, risk identification, resource planning, and continuous improvement
- ● Identify and implement new technologies, analytical approaches, and external capabilities that expand the pharmacology toolkit
- ● Mentor scientists and research associates, providing technical guidance and maintaining a high bar for rigor, reproducibility, documentation, and scientific interpretation
- ● Serve as a scientific leader across functions and external collaborations, integrating molecular and in vivo evidence into program strategy and scientific communications
Требования
- ● PhD in Molecular Biology, Biochemistry, Genetics, Pharmacology, Bioengineering, or a related field, or an equivalent combination of advanced training and relevant industry experience
- ● Deep hands-on experience with quantitative PCR methods and molecular assay development, including work with complex tissue or biofluid samples
- ● Demonstrated ability to design pharmacology studies, interpret pharmacokinetic and pharmacodynamic readouts, and integrate molecular results with cross-functional datasets
- ● Experience with RNA therapeutic development including preclinical pharmacology data preparation and presentation for scientific and regulatory interactions.
- ● Ability to work on site in our laboratory at Research Park at Marina Village in Alameda, California