Senior Research Associate / Scientist, Proteomics Sample Prep

1 нед. назад

USASeniorOnsite

mass spectrometrysample preparation

Senior Research Associate / Scientist role focusing on proteomics sample preparation and mass spectrometry operation, working hands-on in a laboratory setting.

Требования

We're seeking a hands-on, detail-oriented Senior Research Associate / Scientist I to join our proteomics team and help scale our sample processing capacity. Sample volume is growing quickly, and we need someone who can take on the day-to-day execution of tissue and cell sample preparation and mass spec operation.
Reporting to our principal proteomics scientist, you'll spend most of your time at the bench. You'll follow established SOPs closely, prepare and run high volumes of samples, and help keep our Astral mass spec calibrated, well-maintained, and running smoothly. This is a wonderful opportunity to gain hands-on training on the Orbitrap Astral Zoom + Vanquish Neo platform from an experienced mass spec scientist, and growing ownership of the workflow as our automated systems come fully online.
This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

Условия

Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Другое

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.
Prepare tissue and cell samples for mass spectrometry–based proteomics, including precise tissue dissection and cell pellet processing
Execute established protein and peptide enrichment strategies, including cell-surface labeling and immunopeptidomics workflows
Follow validated protocols for protein extraction and purification across a range of sample types
Utilize automation to achieve a sample throughput at 96x plate format scale.
Learn Orbitrap Astral Zoom operation and troubleshooting
Operate and maintain the Orbitrap Astral Zoom, including routine instrument calibration
Follow established SOPs closely to ensure consistent, reliable instrument performance
Work closely with the proteomics and cross-functional teams to keep sample processing on schedule
Document methods and maintain SOPs to support consistent, reproducible results
Communicate proactively, surfacing issues early rather than letting them surface downstream
Required :
Industry or Academic experience relevant to the role and a degree in Proteomics, Chemical Biology, Biochemistry, Analytical Chemistry, or a related field including:
BS/MS with 2+/0+ years (Senior Research Associate)
BS/MS with 4+/2+ years (Scientist I)
Hands-on experience with LC–MS/MS–based proteomics
Experience processing precious, complex clinical samples to include tissue dissection and cell pellet handling
Demonstrated experience in sample preparation, protein extraction, and enrichment strategies (chemical biology/enrichment strategies preferred)
Familiarity with data independent acquisition (DIA)
Excellent problem-solving skills and attention to detail
Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds
Ability to thrive in a fast-paced environment with evolving priorities
Occasional weekend availability required (~1-2 hours) 
Nice to have :
Experience with Thermo Orbitrap mass specs and Vanquish Neo LCs
Experience with cell surface proteomics or chemical labeling approaches
Familiarity with immunopeptidomics workflows (MHC-I/MHC-II)
Experience with performing LC-MS/MS on low-input samples (single-cell, spatial proteomics, immunopeptidomics)
Familiarity with high-throughput proteomics workflows,  automation and sample multiplexing
Understanding of protein chemistry, post-translational modifications, and quantitative proteomics
Basic knowledge of bioinformatics tools or scripting (e.g., R, Python)
We’re looking for a teammate that :
Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.
Treats obstacles as problems to be creatively solved, not reasons something can’t be done.
Applies sound judgment to the best available information, testing, learning, and iterating.
Shares early and directly when assumptions change, results are unclear, or timelines are at risk.
Work environment :
Collaborative culture where your ideas and expertise are valued
Professional growth :
Learn from a diverse team of world-class scientists and engineers
Opportunity to learn and operate state-of-the-art proteomics instruments
Compensation
Estimated Base Salary $82,000-$129,150
This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.