General DiffUSE Job Application

Other

• DiffUSE is a project at the Astera Institute building open infrastructure for studying protein dynamics directly from experimental data. We work at the interface of structural biology (crystallography, cryo-EM), modern machine learning, computational biophysics, and open scientific tooling. Our team spans computational biologists, ML researchers, software engineers, and program staff, collaborating across Astera, Radial, and partner institutions.
• We are growing, and we want to hear from people who would be excited to join us, even if we have not yet posted the specific role that fits you.
• Submit your CV and one paragraph telling us what you can contribute to diffUSE
• We review submissions on a rolling basis
• If there is a fit now or in the near future, we will reach out
• We will only respond if we are interested in exploring further
• Diffraction data processing and structural data pipelines
• Multiconformer and heterogeneity analysis from large datasets
• Data standards work (mmCIF and related)
• Macromolecular ensemble metrics
• Representation learning for protein dynamics
• ML on raw experimental data rather than processed structures
• 3D vision and geometric deep learning backgrounds especially welcome
• Designing and running campaigns to generate large structural datasets
• Partnering with external collaborators to open and standardize existing datasets
• Bridging experimental facilities, data producers, and the open-science community
• Scientific data infrastructure, pipelines, and tooling
• Open-source release engineering, reproducibility, and developer experience
• Program management, scientific coordination, communications
• Open-science publishing and community building
• Familiarity with protein biophysics and the experimental methods that generate structural data
• High agency: you identify what needs doing and move it forward without waiting for direction
• Ability to drive projects and people, including collaborators outside your reporting line
• Comfortable owning a problem end-to-end and unblocking collaborators
• Strong commitment to open science and public-good infrastructure
• Comfort working at the boundary between disciplines
• Bias toward shipping, iteration, and rapid feedback
• Clear written and verbal communication
• Track record of independent work inside collaborative teams
• Location: in-person at Astera in Emeryville, California
• Astera is a 501(c)(3) private operating foundation
• This is not an application to a specific posted role; we will reach out only if there is a fit
• Send your CV
• Include one short paragraph: which role category, and why DiffUSE specifically